Visualizing the Dynamic Metalation State of New Delhi Metallo-β-lactamase-1 in Bacteria Using a Reversible Fluorescent Probe

New Delhi metallo-β-lactamase (NDM) grants resistance to a broad spectrum of β-lactam antibiotics, including last-resort carbapenems, and is emerging as a global antibiotic resistance threat. Limited zinc availability adversely impacts the ability of NDM-1 to provide resistance, but a number of clin...

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Udgivet i:J Am Chem Soc
Main Authors: Mehta, Radhika, Rivera, Dann D., Reilley, David J., Tan, Dominique, Thomas, Pei W., Hinojosa, Abigail, Stewart, Alesha C., Cheng, Zishuo, Thomas, Caitlyn A., Crowder, Michael W., Alexandrova, Anastassia N., Fast, Walter, Que, Emily L.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8230704/
https://ncbi.nlm.nih.gov/pubmed/34038127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c00290
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