Učitavanje...
Iminodiacetic Acid as a Novel Metal-binding Pharmacophore for New Delhi Metallo-β-lactamase Inhibitor Development
The fungal natural product Aspergillomarasmine A (AMA) has been identified as a non-competitive inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1) that inhibits via active site Zn(II) removal. The non-selective metal-chelating properties and the difficult synthesis and derivatization of AMA have h...
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| Izdano u: | ChemMedChem |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7434514/ https://ncbi.nlm.nih.gov/pubmed/32315115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000123 |
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