Elusive structural changes of New Delhi metallo-β-lactamase revealed by ultraviolet photodissociation mass spectrometry

We use mass spectrometry (MS), under denaturing and non-denaturing solution conditions, along with ultraviolet photodissociation (UVPD) to characterize structural variations in New Delhi metallo-β-lactamase (NDM) upon perturbation by ligands or mutation. Mapping changes in the abundances and distrib...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Mehaffey, M. Rachel, Ahn, Yeong-Chan, Rivera, Dann D., Thomas, Pei W., Cheng, Zishuo, Crowder, Michael W., Pratt, R. F., Fast, Walter, Brodbelt, Jennifer S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163344/
https://ncbi.nlm.nih.gov/pubmed/34123154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc02503h
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