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A Lysine-Targeted Affinity Label for Serine β-Lactamase Also Covalently Modifies New Delhi Metallo-β-Lactamase-1 (NDM-1)
The divergent sequences, protein structures, and catalytic mechanisms of serine- and metallo-β- lactamases hamper the development of wide-spectrum β-lactamase inhibitors that can block both types of enzymes. The O-aryloxycarbonyl hydroxamate inactivators of Enterobacter cloacae P99 class C serine-β-...
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| Publicado no: | Biochemistry |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6597302/ https://ncbi.nlm.nih.gov/pubmed/31145588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00393 |
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