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Disease Mechanisms and Therapeutic Approaches in C9orf72 ALS-FTD
A hexanucleotide repeat expansion mutation in the first intron of C9orf72 is the most common known genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Since the discovery in 2011, numerous pathogenic mechanisms, including both loss and gain of function, have been proposed. Th...
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| Publié dans: | Biomedicines |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8229688/ https://ncbi.nlm.nih.gov/pubmed/34070550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9060601 |
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