Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma

BACKGROUND: Reprogramming of metabolic pathways is crucial to satisfy the bioenergetic and biosynthetic demands and maintain the redox status of rapidly proliferating cancer cells. In tumors, the tricarboxylic acid (TCA) cycle generates biosynthetic intermediates and must be replenished (anaplerosis...

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Опубликовано в: :Cancer Metab
Главные авторы: Khadka, Sunada, Arthur, Kenisha, Barekatain, Yasaman, Behr, Eliot, Washington, Mykia, Ackroyd, Jeffrey, Crowley, Kaitlyn, Suriyamongkol, Pornpa, Lin, Yu-Hsi, Pham, Cong-Dat, Zielinski, Rafal, Trujillo, Marissa, Galligan, James, Georgiou, Dimitra K., Asara, John, Muller, Florian
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2021
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228515/
https://ncbi.nlm.nih.gov/pubmed/34172075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-021-00259-4
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