Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma

BACKGROUND: Reprogramming of metabolic pathways is crucial to satisfy the bioenergetic and biosynthetic demands and maintain the redox status of rapidly proliferating cancer cells. In tumors, the tricarboxylic acid (TCA) cycle generates biosynthetic intermediates and must be replenished (anaplerosis...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Khadka, Sunada, Arthur, Kenisha, Barekatain, Yasaman, Behr, Eliot, Washington, Mykia, Ackroyd, Jeffrey, Crowley, Kaitlyn, Suriyamongkol, Pornpa, Lin, Yu-Hsi, Pham, Cong-Dat, Zielinski, Rafal, Trujillo, Marissa, Galligan, James, Georgiou, Dimitra K., Asara, John, Muller, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228515/
https://ncbi.nlm.nih.gov/pubmed/34172075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-021-00259-4
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