Bioreducible Phosphonoamidate Pro-drug Inhibitor of Enolase: Proof of Concept Study

[Image: see text] Glycolysis inhibition remains aspirational in cancer therapy. We recently described a promising phosphonate inhibitor of enolase for cancers harboring homozygous deletions of ENO1. Here, we describe the application of a nitroheterocycle phosphonoamidate pro-drug pair to capitalize...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Yan, Victoria C., Yang, Kristine L., Ballato, Elliot S., Khadka, Sunada, Shrestha, Prakriti, Arthur, Kenisha, Georgiou, Dimitra K., Washington, Mykia, Tran, Theresa, Poral, Anton H., Pham, Cong-Dat, Yan, Matthew J., Muller, Florian L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357215/
https://ncbi.nlm.nih.gov/pubmed/32676158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00203
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