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Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases

The 26S proteasome is the principal protease for regulated intracellular proteolysis. This multi-subunit complex is also pivotal for clearance of harmful proteins that are produced throughout the lifetime of eukaryotes. Recent structural and kinetic studies have revealed a multitude of conformationa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Moon, Seonghyeon, Muniyappan, Srinivasan, Lee, Sung-Bae, Lee, Byung-Hoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226605/
https://ncbi.nlm.nih.gov/pubmed/34207520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126213
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