Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation

Common genetic variants at the RIN3 locus on chromosome 14q32 predispose to Paget’s disease of bone (PDB) but the mechanisms by which they do so are unknown. Here, we analysed the skeletal phenotype of female mice with targeted inactivation of the mouse Rin3 gene (Rin3(−/−)) as compared with wild-ty...

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Publicat a:Calcif Tissue Int
Autors principals: Vallet, Mahéva, Sophocleous, Antonia, Törnqvist, Anna E., Azfer, Asim, Hof, Rob van’t, Albagha, Omar ME, Ralston, Stuart H.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2021
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225545/
https://ncbi.nlm.nih.gov/pubmed/33725152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-021-00827-2
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