Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation

Common genetic variants at the RIN3 locus on chromosome 14q32 predispose to Paget’s disease of bone (PDB) but the mechanisms by which they do so are unknown. Here, we analysed the skeletal phenotype of female mice with targeted inactivation of the mouse Rin3 gene (Rin3(−/−)) as compared with wild-ty...

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Bibliografski detalji
Izdano u:Calcif Tissue Int
Glavni autori: Vallet, Mahéva, Sophocleous, Antonia, Törnqvist, Anna E., Azfer, Asim, Hof, Rob van’t, Albagha, Omar ME, Ralston, Stuart H.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2021
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225545/
https://ncbi.nlm.nih.gov/pubmed/33725152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-021-00827-2
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