Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation

Common genetic variants at the RIN3 locus on chromosome 14q32 predispose to Paget’s disease of bone (PDB) but the mechanisms by which they do so are unknown. Here, we analysed the skeletal phenotype of female mice with targeted inactivation of the mouse Rin3 gene (Rin3(−/−)) as compared with wild-ty...

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Dettagli Bibliografici
Pubblicato in:Calcif Tissue Int
Autori principali: Vallet, Mahéva, Sophocleous, Antonia, Törnqvist, Anna E., Azfer, Asim, Hof, Rob van’t, Albagha, Omar ME, Ralston, Stuart H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2021
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225545/
https://ncbi.nlm.nih.gov/pubmed/33725152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-021-00827-2
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