Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification

Calcification is a prominent feature of late-stage atherosclerosis, but the mechanisms driving this process are unclear. Using a biobank of carotid endarterectomies, we recently showed that Proteoglycan 4 (PRG4) is a key molecular signature of calcified plaques, expressed in smooth muscle cell (SMC)...

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Vydáno v:Cells
Hlavní autoři: Seime, Till, Akbulut, Asim Cengiz, Liljeqvist, Moritz Lindquist, Siika, Antti, Jin, Hong, Winski, Greg, van Gorp, Rick H., Karlöf, Eva, Lengquist, Mariette, Buckler, Andrew J., Kronqvist, Malin, Waring, Olivia J., Lindeman, Jan H. N., Biessen, Erik A. L., Maegdefessel, Lars, Razuvaev, Anton, Schurgers, Leon J., Hedin, Ulf, Matic, Ljubica
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8224064/
https://ncbi.nlm.nih.gov/pubmed/34063989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10061276
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