Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification

Calcification is a prominent feature of late-stage atherosclerosis, but the mechanisms driving this process are unclear. Using a biobank of carotid endarterectomies, we recently showed that Proteoglycan 4 (PRG4) is a key molecular signature of calcified plaques, expressed in smooth muscle cell (SMC)...

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Publicado no:Cells
Main Authors: Seime, Till, Akbulut, Asim Cengiz, Liljeqvist, Moritz Lindquist, Siika, Antti, Jin, Hong, Winski, Greg, van Gorp, Rick H., Karlöf, Eva, Lengquist, Mariette, Buckler, Andrew J., Kronqvist, Malin, Waring, Olivia J., Lindeman, Jan H. N., Biessen, Erik A. L., Maegdefessel, Lars, Razuvaev, Anton, Schurgers, Leon J., Hedin, Ulf, Matic, Ljubica
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8224064/
https://ncbi.nlm.nih.gov/pubmed/34063989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10061276
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