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Myc and the Replicative CMG Helicase: The Creation and Destruction of Cancer
Myc-driven tumorigenesis involves a non-transcriptional role for Myc in over-activating replicative Cdc45-MCM-GINS (CMG) helicases. Excessive stimulation of CMG helicases by Myc mismanages CMG function by diminishing the number of reserve CMGs necessary for fidelity of DNA replication and recovery f...
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| Publié dans: | Bioessays |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8223603/ https://ncbi.nlm.nih.gov/pubmed/32080866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201900218 |
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