Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling

Patients with long-standing diabetes have a high risk for cardiac complications that is exacerbated by increased reactive oxygen species (ROS) production. We found that feeding cyanocobalamin (B12), a scavenger of superoxide, not only prevented but reversed signs of cardiomyopathy in type 1 diabetic...

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Pubblicato in:Commun Biol
Autori principali: Kakoki, Masao, Ramanathan, Purushotham V., Hagaman, John R., Grant, Ruriko, Wilder, Jennifer C., Taylor, Joan M., Charles Jennette, J., Smithies, Oliver, Maeda-Smithies, Nobuyo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222371/
https://ncbi.nlm.nih.gov/pubmed/34163008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02291-y
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