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Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G(4)C(2) RNA in a cellular model
The most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia is a G(4)C(2) repeat expansion in the C9orf72 gene. This expansion gives rise to translation of aggregating dipeptide repeat (DPR) proteins, including poly-GA as the most abundant species. However, gain of t...
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| Publicado en: | eLife |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8221807/ https://ncbi.nlm.nih.gov/pubmed/34161229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62718 |
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