Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [(11)C]erlotinib

P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict at the blood–brain barrier (BBB) the brain distribution of the majority of currently known molecularly targeted anticancer drugs. To improve brain delivery of dual ABCB1/ABCG2 substrates, both ABCB1 and ABCG2 need to be inh...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Tournier, Nicolas, Goutal, Sebastien, Mairinger, Severin, Hernández-Lozano, Irene, Filip, Thomas, Sauberer, Michael, Caillé, Fabien, Breuil, Louise, Stanek, Johann, Freeman, Anna F, Novarino, Gaia, Truillet, Charles, Wanek, Thomas, Langer, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221757/
https://ncbi.nlm.nih.gov/pubmed/33081568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X20965500
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