RNAi screening of the kinome with cytarabine in leukemias

To identify rational therapeutic combinations with cytarabine (Ara-C), we developed a high-throughput, small-interference RNA (siRNA) platform for myeloid leukemia cells. Of 572 kinases individually silenced in combination with Ara-C, silencing of 10 (1.7%) and 8 (1.4%) kinases strongly increased Ar...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Tibes, Raoul, Bogenberger, James M., Chaudhuri, Leena, Hagelstrom, R. Tanner, Chow, Donald, Buechel, Megan E., Gonzales, Irma M., Demuth, Tim, Slack, James, Mesa, Ruben A., Braggio, Esteban, Yin, Hongwei H., Arora, Shilpi, Azorsa, David O.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221104/
https://ncbi.nlm.nih.gov/pubmed/22267604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-367557
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