RNAi screening of the kinome with cytarabine in leukemias

To identify rational therapeutic combinations with cytarabine (Ara-C), we developed a high-throughput, small-interference RNA (siRNA) platform for myeloid leukemia cells. Of 572 kinases individually silenced in combination with Ara-C, silencing of 10 (1.7%) and 8 (1.4%) kinases strongly increased Ar...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Tibes, Raoul, Bogenberger, James M., Chaudhuri, Leena, Hagelstrom, R. Tanner, Chow, Donald, Buechel, Megan E., Gonzales, Irma M., Demuth, Tim, Slack, James, Mesa, Ruben A., Braggio, Esteban, Yin, Hongwei H., Arora, Shilpi, Azorsa, David O.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221104/
https://ncbi.nlm.nih.gov/pubmed/22267604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-367557
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