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Directed regioselective ortho,ortho′-magnesiations of aromatics and heterocycles using sBu(2)Mg in toluene

Aryl azoles are ubiquitous as bioactive compounds and their regioselective functionalization is of utmost synthetic importance. Here, we report the development of a toluene-soluble dialkylmagnesium base sBu(2)Mg. This new reagent allows mild and regioselective ortho-magnesiations of various N-arylat...

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Publicado en:Chem Sci
Main Authors: Hess, Andreas, Prohaska, Jan P., Doerrich, Sabrina B., Trauner, Florian, Lutter, Ferdinand H., Lemaire, Sébastien, Wagschal, Simon, Karaghiosoff, Konstantin, Knochel, Paul
Formato: Artigo
Idioma:Inglês
Publicado: The Royal Society of Chemistry 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221067/
https://ncbi.nlm.nih.gov/pubmed/34221323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc01777b
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