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Regioselective Bromine/Magnesium Exchange for the Selective Functionalization of Polyhalogenated Arenes and Heterocycles

Using the bimetallic combination sBu(2)Mg⋅2 LiOR (R=2‐ethylhexyl) in toluene enables efficient and regioselective Br/Mg exchanges with various dibromo‐arenes and ‐heteroarenes under mild reaction conditions and provides bromo‐substituted magnesium reagents. Assessing the role of Lewis donor additive...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Desaintjean, Alexandre, Haupt, Tobias, Bole, Leonie J., Judge, Neil R., Hevia, Eva, Knochel, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839478/
https://ncbi.nlm.nih.gov/pubmed/33079466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202012496
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