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Generation and Regioselective Trapping of a 3,4-Piperidyne for the Synthesis of Functionalized Heterocycles

We report the generation of the first 3,4-piperidyne and its use as a building block for the synthesis of annulated piperidines. Experimental and computational studies of this intermediate are disclosed, along with comparisons to the well-known 3,4-pyridyne. The distortion/interaction model is used...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Am Chem Soc
Päätekijät: McMahon, Travis C., Medina, Jose M., Yang, Yun-Fang, Simmons, Bryan J., Houk, K. N., Garg, Neil K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502428/
https://ncbi.nlm.nih.gov/pubmed/25768436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b01589
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