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The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling
MLKL phosphorylation by RIP3 is the commitment step of necroptosis execution, which could induce MLKL activation featured as MLKL monomer-oligomer transition. Here, we reported that the dimerization of the MLKL kinase-like domain was the direct consequence of RIP3 triggered MLKL-phosphorylation. Two...
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| Publicado no: | Cell Death Dis |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8219780/ https://ncbi.nlm.nih.gov/pubmed/34158471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03859-6 |
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