Multimechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection

In a rabbit model of methicillin-resistant Staphylococcus aureus prosthetic joint infection (PJI), prophylaxis with AZD6389*—a combination of three monoclonal antibodies targeting alpha-hemolysin, bicomponent cytotoxins (LukSF/LukED/HlgAB/HlgCB), and clumping factor A—resulted in significant reducti...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Mao, Yanjie, Valour, Florent, Nguyen, Nhu T. Q., Doan, Thien M. N., Koelkebeck, Holly, Richardson, Christopher, Cheng, Lily I., Sellman, Bret R., Tkaczyk, Christine, Diep, Binh An
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218614/
https://ncbi.nlm.nih.gov/pubmed/33903108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01832-20
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