Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice

Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus. We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy c...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Ortines, Roger V., Wang, Yu, Liu, Haiyun, Dikeman, Dustin A., Pinsker, Bret L., Miller, Robert J., Kim, Sophia E., Ackerman, Nicole E., Rizkallah, Joe F., Marcello, LeeAnn T., Cohen, Taylor S., Tkaczyk, Christine, Sellman, Bret R., Miller, Lloyd S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658795/
https://ncbi.nlm.nih.gov/pubmed/31138566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00346-19
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