Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice

Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus. We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy c...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Ortines, Roger V., Wang, Yu, Liu, Haiyun, Dikeman, Dustin A., Pinsker, Bret L., Miller, Robert J., Kim, Sophia E., Ackerman, Nicole E., Rizkallah, Joe F., Marcello, LeeAnn T., Cohen, Taylor S., Tkaczyk, Christine, Sellman, Bret R., Miller, Lloyd S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658795/
https://ncbi.nlm.nih.gov/pubmed/31138566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00346-19
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