Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia

Staphylococcus aureus is a major human pathogen that causes a wide range of infections by producing an arsenal of cytotoxins. We found that passive immunization with either a monoclonal antibody (MAb) neutralizing alpha-hemolysin or a broadly cross-reactive MAb neutralizing Panton-Valentine leukocid...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Vu, Trang T. T., Nguyen, Nhu T. Q., Tran, Vuvi G., Gras, Emmanuelle, Mao, Yanjie, Jung, David H., Tkaczyk, Christine, Sellman, Bret R., Diep, Binh An
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038280/
https://ncbi.nlm.nih.gov/pubmed/31844012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02220-19
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