Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice

Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus. We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy c...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Ortines, Roger V., Wang, Yu, Liu, Haiyun, Dikeman, Dustin A., Pinsker, Bret L., Miller, Robert J., Kim, Sophia E., Ackerman, Nicole E., Rizkallah, Joe F., Marcello, LeeAnn T., Cohen, Taylor S., Tkaczyk, Christine, Sellman, Bret R., Miller, Lloyd S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2019
Gaiak:
Experimental Therapeutics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658795/
https://ncbi.nlm.nih.gov/pubmed/31138566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00346-19
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