Heparanase expression and activity are increased in platelets during clinical sepsis

BACKGROUND: Heparanase (HPSE) is the only known mammalian enzyme that can degrade heparan sulfate. Heparan sulfate proteoglycans are essential components of the glycocalyx, and maintain physiological barriers between the blood and endothelial cells. HPSE increases during sepsis, which contributes to...

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Publicado en:J Thromb Haemost
Autores principales: Eustes, Alicia S., Campbell, Robert A., Middleton, Elizabeth A., Tolley, Neal D., Manne, Bhanu K., Montenont, Emilie, Rowley, Jesse W., Krauel, Krystin, Blair, Antoinette, Guo, Li, Kosaka, Yasuhiro, Medeiros- de- Moraes, Isabel M., Lacerda, Marcus, Hottz, Eugenio D., Neto, Hugo Castro Faria, Zimmerman, Guy A., Weyrich, Andrew S., Petrey, Aaron, Rondina, Matthew T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218538/
https://ncbi.nlm.nih.gov/pubmed/33587773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15266
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