Heparanase expression and activity are increased in platelets during clinical sepsis

BACKGROUND: Heparanase (HPSE) is the only known mammalian enzyme that can degrade heparan sulfate. Heparan sulfate proteoglycans are essential components of the glycocalyx, and maintain physiological barriers between the blood and endothelial cells. HPSE increases during sepsis, which contributes to...

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Eustes, Alicia S., Campbell, Robert A., Middleton, Elizabeth A., Tolley, Neal D., Manne, Bhanu K., Montenont, Emilie, Rowley, Jesse W., Krauel, Krystin, Blair, Antoinette, Guo, Li, Kosaka, Yasuhiro, Medeiros- de- Moraes, Isabel M., Lacerda, Marcus, Hottz, Eugenio D., Neto, Hugo Castro Faria, Zimmerman, Guy A., Weyrich, Andrew S., Petrey, Aaron, Rondina, Matthew T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218538/
https://ncbi.nlm.nih.gov/pubmed/33587773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15266
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