CRISPR-edited megakaryocytes for rapid screening of platelet gene functions

Human anucleate platelets cannot be directly modified using traditional genetic approaches. Instead, studies of platelet gene function depend on alternative models. Megakaryocytes (the nucleated precursor to platelets) are the nearest cell to platelets in origin, structure, and function. However, ac...

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Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Montenont, Emilie, Bhatlekar, Seema, Jacob, Shancy, Kosaka, Yasuhiro, Manne, Bhanu K., Lee, Olivia, Parra-Izquierdo, Ivan, Tugolukova, Emilia, Tolley, Neal D., Rondina, Matthew T., Bray, Paul F., Rowley, Jesse W.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2021
Matèries:
Platelets and Thrombopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8114553/
https://ncbi.nlm.nih.gov/pubmed/33944898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020004112
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