CRISPR-edited megakaryocytes for rapid screening of platelet gene functions

Human anucleate platelets cannot be directly modified using traditional genetic approaches. Instead, studies of platelet gene function depend on alternative models. Megakaryocytes (the nucleated precursor to platelets) are the nearest cell to platelets in origin, structure, and function. However, ac...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Montenont, Emilie, Bhatlekar, Seema, Jacob, Shancy, Kosaka, Yasuhiro, Manne, Bhanu K., Lee, Olivia, Parra-Izquierdo, Ivan, Tugolukova, Emilia, Tolley, Neal D., Rondina, Matthew T., Bray, Paul F., Rowley, Jesse W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8114553/
https://ncbi.nlm.nih.gov/pubmed/33944898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020004112
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