METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding

The adenomatous polyposis coli (APC) is a frequently mutated tumour suppressor gene in cancers. However, whether APC is regulated at the epitranscriptomic level remains elusive. In this study, we analysed TCGA data and separated 200 paired oesophageal squamous cell carcinoma (ESCC) specimens and the...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Wang, Wei, Shao, Fei, Yang, Xueying, Wang, Juhong, Zhu, Rongxuan, Yang, Yannan, Zhao, Gaoxiang, Guo, Dong, Sun, Yingli, Wang, Jie, Xue, Qi, Gao, Shugeng, Gao, Yibo, He, Jie, Lu, Zhimin
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217513/
https://ncbi.nlm.nih.gov/pubmed/34155197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23501-5
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