WNT/β-catenin-suppressed FTO expression increases m(6)A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis

FTO removes the N6-methyladenosine (m(6)A) modification from genes and plays a critical role in cancer development. However, the mechanisms underlying the regulation of FTO and its subsequent impact on the regulation of the epitranscriptome remain to be further elucidated. Here, we demonstrate that...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Yang, Xueying, Shao, Fei, Guo, Dong, Wang, Wei, Wang, Juhong, Zhu, Rongxuan, Gao, Yibo, He, Jie, Lu, Zhimin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106678/
https://ncbi.nlm.nih.gov/pubmed/33966037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03739-z
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