Autophagy of the m(6)A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis

Here we show that FTO as an N(6)-methyladenosine (m(6)A) RNA demethylase is degraded by selective autophagy, which is impaired by low-level arsenic exposure to promote tumorigenesis. We found that in arsenic-associated human skin lesions, FTO is upregulated, while m(6)A RNA methylation is downregula...

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Publicat a:Nat Commun
Autors principals: Cui, Yan-Hong, Yang, Seungwon, Wei, Jiangbo, Shea, Christopher R., Zhong, Wen, Wang, Fang, Shah, Palak, Kibriya, Muhammad G., Cui, Xiaolong, Ahsan, Habibul, He, Chuan, He, Yu-Ying
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041927/
https://ncbi.nlm.nih.gov/pubmed/33846348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22469-6
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