m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N(6)-methyladenosine (m(6)A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade immunotherapy. FTO level is increased in human m...

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Publicado en:Nat Commun
Main Authors: Yang, Seungwon, Wei, Jiangbo, Cui, Yan-Hong, Park, Gayoung, Shah, Palak, Deng, Yu, Aplin, Andrew E., Lu, Zhike, Hwang, Seungmin, He, Chuan, He, Yu-Ying
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592937/
https://ncbi.nlm.nih.gov/pubmed/31239444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10669-0
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