Differential m(6)A, m(6)A(m), and m(1)A Demethylation Mediated by FTO in Cell Nucleus and Cytoplasm

FTO, the first RNA demethylase discovered, mediates the demethylation of internal N(6)-methyladenosine (m(6)A) and N(6), 2-O-dimethyladenosine (m(6)A(m)) at the +1 position from the 5’ cap in mRNA. Here, we demonstrate that the cellular distribution of FTO is distinct among different cell lines, aff...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Wei, Jiangbo, Liu, Fange, Lu, Zhike, Fei, Qili, Ai, Yuxi, He, P. Cody, Shi, Hailing, Cui, Xiaolong, Su, Rui, Klungland, Arne, Jia, Guifang, Chen, Jianjun, He, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151148/
https://ncbi.nlm.nih.gov/pubmed/30197295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.011
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