Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates

Targeting MAIT cells holds promise for the treatment of different diseases and infections. We previously showed that treatment of Mycobacterium tuberculosis infected mice with 5-OP-RU, a major antigen for MAIT cells, expands MAIT cells and enhances bacterial control. Here we treated M. tuberculosis...

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Bibliografiska uppgifter
I publikationen:Mucosal Immunol
Huvudupphovsmän: Sakai, Shunsuke, Lora, Nickiana E., Kauffman, Keith D., Dorosky, Danielle E., Oh, Sangmi, Namasivayam, Sivaranjani, Gomez, Felipe, Fleegle, Joel D., Arlehamn, Cecilia S. Lindestam, Sette, Alessandro, Sher, Alan, Freeman, Gordon J., Via, Laura E., Barry III, Clifton E., Barber, Daniel L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group US 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217205/
https://ncbi.nlm.nih.gov/pubmed/34158594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-021-00425-3
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