Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates

Targeting MAIT cells holds promise for the treatment of different diseases and infections. We previously showed that treatment of Mycobacterium tuberculosis infected mice with 5-OP-RU, a major antigen for MAIT cells, expands MAIT cells and enhances bacterial control. Here we treated M. tuberculosis...

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Gepubliceerd in:Mucosal Immunol
Hoofdauteurs: Sakai, Shunsuke, Lora, Nickiana E., Kauffman, Keith D., Dorosky, Danielle E., Oh, Sangmi, Namasivayam, Sivaranjani, Gomez, Felipe, Fleegle, Joel D., Arlehamn, Cecilia S. Lindestam, Sette, Alessandro, Sher, Alan, Freeman, Gordon J., Via, Laura E., Barry III, Clifton E., Barber, Daniel L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group US 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217205/
https://ncbi.nlm.nih.gov/pubmed/34158594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-021-00425-3
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