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Cullin-RING Ubiquitin Ligase Regulatory Circuits: a Quarter Century Beyond the F-box Hypothesis
Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad biological processes through target-specific ubiquitylation. Our knowledge of this system emerged from the F-box hypothesis, posited a quarter century ago: numerous interchangeable F-box proteins confer specific...
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| Udgivet i: | Annu Rev Biochem |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8217159/ https://ncbi.nlm.nih.gov/pubmed/33823649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biochem-090120-013613 |
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