Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer

The homeostatic oxygen sensing system (HOSS) optimizes systemic oxygen delivery. Specialized tissues utilize a conserved mitochondrial sensor, often involving NDUFS2 in complex I of the mitochondrial electron transport chain, as a site of pO(2)-responsive production of reactive oxygen species (ROS)....

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Wu, Danchen, Dasgupta, Asish, Read, Austin D., Bentley, Rachel E.T., Motamed, Mehras, Chen, Kuang-Hueih, Al-Qazazi, Ruaa, Mewburn, Jeffrey D., Dunham-Snary, Kimberly J., Alizadeh, Elahe, Tian, Lian, Archer, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217091/
https://ncbi.nlm.nih.gov/pubmed/33450375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.12.452
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