Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities

Introduction: Group 2 pulmonary hypertension (PH), defined as a mean pulmonary arterial pressure ≥25 mmHg with elevated pulmonary capillary wedge pressure >15 mmHg, has no approved therapy and patients often die from right ventricular failure (RVF). Alterations in mitochondrial metabolism, notabl...

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Veröffentlicht in:Front Cardiovasc Med
Hauptverfasser: Xiong, Ping Yu, Tian, Lian, Dunham-Snary, Kimberly J., Chen, Kuang-Hueih, Mewburn, Jeffrey D., Neuber-Hess, Monica, Martin, Ashley, Dasgupta, Asish, Potus, Francois, Archer, Stephen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Cardiovascular Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355690/
https://ncbi.nlm.nih.gov/pubmed/30740395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2018.00195
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