Epigenetic dysregulation of the Drp1 binding partners MiD49 and MiD51 increases mitotic mitochondrial fission and promotes pulmonary arterial hypertension: mechanistic and therapeutic implications

BACKGROUND: Mitotic fission is increased in pulmonary arterial hypertension (PAH), a hyperproliferative, apoptosis-resistant disease. The fission mediator, dynamin related protein 1 (Drp1) must complex with adaptor proteins to cause fission. Drp1-induced fission has been therapeutically targeted in...

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Pubblicato in:Circulation
Autori principali: Chen, Kuang-Hueih, Dasgupta, Asish, Lin, Jianhui, Potus, Francois, Bonnet, Sebastien, Iremonger, James, Fu, Jennifer, Mewburn, Jeffrey, Wu, Danchen, Dunham-Snary, Kimberly, Theilmann, Anne L., Jing, Zhi-Cheng, Hindmarch, Charles, Ormiston, Mark L., Lawrie, Allan, Archer, Stephen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050130/
https://ncbi.nlm.nih.gov/pubmed/29431643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.031258
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