Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension

Introduction: Right ventricular (RV) fibrosis contributes to RV failure in pulmonary arterial hypertension (PAH). The mechanisms underlying RV fibrosis in PAH and the role of RV fibroblasts (RVfib) are unknown. Activation of the mitochondrial fission mediator dynamin-related protein 1 (Drp1) contrib...

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Detalles Bibliográficos
Publicado en:Front Physiol
Main Authors: Tian, Lian, Potus, Francois, Wu, Danchen, Dasgupta, Asish, Chen, Kuang-Hueih, Mewburn, Jeffrey, Lima, Patricia, Archer, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Physiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048272/
https://ncbi.nlm.nih.gov/pubmed/30042687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00828
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