Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis

RATIONALE: Right ventricular (RV) fibrosis in pulmonary arterial hypertension (PAH) contributes to RV failure (RVF). While RV fibrosis reflects changes in the function of resident RV fibroblasts (RVfib), these cells are understudied. OBJECTIVE: Examine the role of mitochondrial metabolism of RVfib i...

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Udgivet i:Circ Res
Main Authors: Tian, Lian, Wu, Danchen, Dasgupta, Asish, Chen, Kuang-Hueih, Mewburn, Jeffrey, Potus, Francois, Lima, Patricia A.D., Hong, Zhigang, Zhao, Yuan-Yuan, Hindmarch, Charles C.T., Kutty, Shelby, Provencher, Steeve, Bonnet, Sebastien, Sutendra, Gopinath, Archer, Stephen L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274861/
https://ncbi.nlm.nih.gov/pubmed/32216531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.120.316443
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