PINK1 induced phosphorylation of mitofusin 2 (Mfn2) at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension

Impaired mitochondrial fusion, due in part to decreased mitofusin 2 (Mfn2) expression, contributes to unrestricted cell proliferation and apoptosis-resistance in hyperproliferative diseases like pulmonary arterial hypertension (PAH) and non-small cell lung cancer (NSCLC). We hypothesized that Mfn2 l...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Dasgupta, Asish, Chen, Kuang-Hueih, Lima, Patricia D.A., Mewburn, Jeffrey, Wu, Danchen, Al-Qazazi, Ruaa, Jones, Oliver, Tian, Lian, Potus, Francois, Bonnet, Sebastien, Archer, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294132/
https://ncbi.nlm.nih.gov/pubmed/34275172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202100361R
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados