CUL5–ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy

p62/SQSTM1 (sequestosome-1) is a key protein involved in multiple cellular bioprocesses including autophagy, nutrient sensing, cell growth, cell death, and survival. Therefore, it is implicated in human diseases such as obesity and cancer. Here, we show that the CUL5–ASB6 complex is a ubiquitin E3 l...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Cell Dev Biol
Main Authors: Gong, Liyan, Wang, Kaihua, Wang, Mengcheng, Hu, Ronggui, Li, Huaguang, Gao, Daming, Lin, Moubin
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Cell and Developmental Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215545/
https://ncbi.nlm.nih.gov/pubmed/34164402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.684885
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