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Autophagy substrate SQSTM1/p62 regulates chromatin ubiquitination during the DNA damage response

The importance of autophagy in the DNA damage repair process is clear; however, the detailed molecular mechanism is still largely unknown. Here we found that DNA damage-induced histone H2A ubiquitination is suppressed in autophagy-deficient cells in a SQSTM1/p62 dependent manner. SQSTM1 binds and in...

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Bibliografske podrobnosti
izdano v:Autophagy
Main Authors: Wang, Yanan, Zhu, Wei-Guo, Zhao, Ying
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240823/
https://ncbi.nlm.nih.gov/pubmed/27791533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1245262
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