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Neddylation Regulates Macrophages and Implications for Cancer Therapy

Tumor-associated macrophages (TAMs) promote cancer progression via stimulating angiogenesis, invasion/metastasis, and suppressing anti-cancer immunity. Targeting TAMs is a potential promising cancer therapeutic strategy. Neddylation adds the ubiquitin-like protein NEDD8 to substrates, and thereby re...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Jiang, Yanyu, Li, Lihui, Li, Yan, Liu, Guangwei, Hoffman, Robert M., Jia, Lijun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215544/
https://ncbi.nlm.nih.gov/pubmed/34164400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.681186
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