Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers

Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. To better define the underlying molecular mechanisms driving...

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發表在:Blood
Main Authors: Fagnan, Alexandre, Bagger, Frederik Otzen, Piqué-Borràs, Maria-Riera, Ignacimouttou, Cathy, Caulier, Alexis, Lopez, Cécile K., Robert, Elie, Uzan, Benjamin, Gelsi-Boyer, Véronique, Aid, Zakia, Thirant, Cécile, Moll, Ute, Tauchmann, Samantha, Kurtovic-Kozaric, Amina, Maciejewski, Jaroslaw, Dierks, Christine, Spinelli, Orietta, Salmoiraghi, Silvia, Pabst, Thomas, Shimoda, Kazuya, Deleuze, Virginie, Lapillonne, Hélène, Sweeney, Connor, De Mas, Véronique, Leite, Betty, Kadri, Zahra, Malinge, Sébastien, de Botton, Stéphane, Micol, Jean-Baptiste, Kile, Benjamin, Carmichael, Catherine L., Iacobucci, Ilaria, Mullighan, Charles G., Carroll, Martin, Valent, Peter, Bernard, Olivier A., Delabesse, Eric, Vyas, Paresh, Birnbaum, Daniel, Anguita, Eduardo, Garçon, Loïc, Soler, Eric, Schwaller, Juerg, Mercher, Thomas
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2020
主題:
Myeloid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215330/
https://ncbi.nlm.nih.gov/pubmed/32350520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003062
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