Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia

The nuclear receptor binding SET domain protein 1 (NSD1) is recurrently mutated in human cancers including acute leukemia. We show that NSD1 knockdown alters erythroid clonogenic growth of human CD34(+) hematopoietic cells. Ablation of Nsd1 in the hematopoietic system of mice induces a transplantabl...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Leonards, Katharina, Almosailleakh, Marwa, Tauchmann, Samantha, Bagger, Frederik Otzen, Thirant, Cécile, Juge, Sabine, Bock, Thomas, Méreau, Hélène, Bezerra, Matheus F., Tzankov, Alexandar, Ivanek, Robert, Losson, Régine, Peters, Antoine H. F. M., Mercher, Thomas, Schwaller, Juerg
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293310/
https://ncbi.nlm.nih.gov/pubmed/32533074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16179-8
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