Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers

Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. To better define the underlying molecular mechanisms driving...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Fagnan, Alexandre, Bagger, Frederik Otzen, Piqué-Borràs, Maria-Riera, Ignacimouttou, Cathy, Caulier, Alexis, Lopez, Cécile K., Robert, Elie, Uzan, Benjamin, Gelsi-Boyer, Véronique, Aid, Zakia, Thirant, Cécile, Moll, Ute, Tauchmann, Samantha, Kurtovic-Kozaric, Amina, Maciejewski, Jaroslaw, Dierks, Christine, Spinelli, Orietta, Salmoiraghi, Silvia, Pabst, Thomas, Shimoda, Kazuya, Deleuze, Virginie, Lapillonne, Hélène, Sweeney, Connor, De Mas, Véronique, Leite, Betty, Kadri, Zahra, Malinge, Sébastien, de Botton, Stéphane, Micol, Jean-Baptiste, Kile, Benjamin, Carmichael, Catherine L., Iacobucci, Ilaria, Mullighan, Charles G., Carroll, Martin, Valent, Peter, Bernard, Olivier A., Delabesse, Eric, Vyas, Paresh, Birnbaum, Daniel, Anguita, Eduardo, Garçon, Loïc, Soler, Eric, Schwaller, Juerg, Mercher, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215330/
https://ncbi.nlm.nih.gov/pubmed/32350520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003062
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